Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
Preclinical study of formulated recombinant nucleocapsid protein, the receptor binding domain of the spike protein, and truncated spike (S1) protein as vaccine candidates against COVID-19 in animal models동물 모델에서 COVID-19에 대한 백신 후보로서 제형화된 재조합 뉴클레오캡시드 단백질, 스파이크 단백질의 수용체 결합 도메인 및 절단 스파이크(S1) 단백질의 전임상 연구Article Published on 2022-09-012022-09-11 Journal: Molecular immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome adjuvants alum alum adjuvant analyzed animal model antibody Antibody titers Antigen AS03 binding candidate vaccine cellular cellular immunity Cellular responses COVID-19 cytokine Cytometry cytotoxicity domain dose doses ELISA evaluated flow cytometry humoral humoral and cellular immunity IgG antibody IgG antibody titer immunization immunization program immunogenic immunogenicity injection mice Mild mild to moderate moderate N-terminal domain not neutralize nucleocapsid protein nucleoprotein pathologic preclinical study primates produced Protein protein antigens RBD Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 sera Severe acute respiratory syndrome Spike protein Strong Subunit vaccine Subunit vaccine. the spike protein Vaccine vaccine candidate virus Virus neutralization VNT was performed was recorded were used [DOI] 10.1016/j.molimm.2022.06.007 PMC 바로가기 [Article Type] Article
Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort인구 기반 코호트에서 SARS-CoV-2 감염 후 뚜렷한 궤적을 가진 이종 체액성 및 세포성 면역 반응Article Published on 2022-08-182022-09-11 Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, 치료법, [키워드] analysis anti-N IgG anti-S responses antibody Antibody responses Cellular immune response cellular immunity cellular response characterized clinical factors Cluster analyses Delta detectable develop Diagnosis FIVE heterogeneity humoral humoral and cellular immunity Humoral and cellular responses identify IgA IgG immune Immunity individual infected individuals Infection maintain membrane Neutralizing activity neutralizing antibody omicron Omicron variants Participants population-based cohort required responses S proteins SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individual T cell T cell response T cell responses T cells trajectory variant [DOI] 10.1038/s41467-022-32573-w PMC 바로가기 [Article Type] Article
BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults이종 프라임-부스트 백신 접종 후 BNT162b2 부스터는 젊은 성인에서 SARS-CoV-2 Omicron BA.1에 대한 강력한 중화 항체 및 T 세포 반응성을 유도합니다Article Published on 2022-07-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adults analysed Antibody titer Antibody titers B.1 B.1.1.529.1 BA.1 BNT162b2 booster Cell cellular immunity ChAdOx1 ChAdOx1 nCoV-19 Cohort Course COVID-19 defined Delta dominant Effect effective elicited Epitopes Heterologous heterologous prime-boost humoral humoral and cellular immunity Humoral immunity immune immune protection immune responses Immunity individual induce initial interval maturation memory T memory T cell memory T cells nCoV neutralization titer neutralization titers neutralized Neutralizing activity neutralizing antibody omicron performed reactivity residual responses against resulting SARS-CoV-2 SARS-COV-2 infection spike epitope spike epitopes subsequent symptomatic SARS-CoV-2 infection T cell T cells the early SARS-CoV-2 vaccination vaccination interval. Vaccinations variant variants variants of concern VOCs [DOI] 10.3389/fimmu.2022.882918 PMC 바로가기 [Article Type] Article
Cellular and Humoral Immune Response to a Third Dose of BNT162b2 COVID-19 Vaccine – A Prospective Observational StudyBNT162b2 COVID-19 백신의 3차 접종에 대한 세포 및 체액 면역 반응 - 전향적 관찰 연구Observational Study Published on 2022-07-012022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료기술, [키워드] addition administration All participant All participants anti-SARS-CoV-2 antibody binding binding antibody blood sample Blood samples BNT162b2 booster booster dose cellular Cellular immune response Combination COVID-19 detectable dose evaluate health-care humoral humoral and cellular immunity Humoral immunity immune response Immunity immunological infection rate infection rates interferon Interferon-gamma median Neutralizing antibodies neutralizing antibody observational study of BNT162b2 participant peptide peptides prime-boost regimen Prospective prospective observational study protocols provided quantitative assay questionnaire Questionnaires real-world data response SARS-CoV-2 second dose Seroprevalence significant increase significantly third dose vaccination vaccination. Vaccine was measured were measured [DOI] 10.3389/fimmu.2022.896151 PMC 바로가기 [Article Type] Observational Study
Evaluation of humoral and cellular response to third dose of BNT162b2 mRNA COVID-19 vaccine in patients treated with B-cell depleting therapyB세포 고갈 요법으로 치료받은 환자에서 BNT162b2 mRNA COVID-19 백신 3차 접종에 대한 체액 및 세포 반응 평가Article Published on 2022-07-012022-09-11 Journal: Journal of autoimmunity [Category] MERS, 바이오마커, 유전자 메커니즘, 진단, [키워드] affected anti-CD20 anti-S anti-SARS-CoV-2 antibody Autoimmune disease B-cell BNT162b2 CD-20 CD20 cellular immunity cellular response Cohort COVID-19 COVID-19 vaccination COVID-19 vaccine depleting dose doses drug group healthy control healthy controls humoral humoral and cellular immunity IFN-g IgG IMID Immune-mediated inflammatory disease Immune-mediated inflammatory diseases immunogenic immunogenicity Immunosuppressed immunosuppressed patient immunosuppressed patients Inflammatory diseases interferon mRNA mRNA COVID-19 vaccine mRNA COVID-19 vaccines naïve Neutralization assay neutralization assays neutralization titer neutralization titers Neutralizing antibodies neutralizing antibody no significant difference of BNT162b2 Patient patients treated Quantitative reduced response seroconverted significant difference significantly spike subject therapy These data treated vaccination vaccination. [DOI] 10.1016/j.jaut.2022.102848 PMC 바로가기 [Article Type] Article
Competent immune responses to SARS-CoV-2 variants in older adults following two doses of mRNA vaccinationmRNA 백신 2회 투여 후 노인의 SARS-CoV-2 변이체에 대한 유능한 면역 반응Article Published on 2022-05-242022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] age aging Antibody titers B.1.617.1 B.1.617.2 boost cellular immunity Cohort comparable Delta dose Efficacy Gamma humoral humoral and cellular immunity Humoral immunity immune response immune responses magnitude mRNA mRNA vaccination mRNA vaccine mRNA-based SARS-CoV-2 vaccine mRNA-based SARS-CoV-2 vaccines Neutralizing antibody titer neutralizing antibody titers neutralizing capacity Older Older adults P.1 recipients reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants second dose second vaccination shown spike mutation vaccination vaccination response vaccinee variant variants Viral virus while [DOI] 10.1038/s41467-022-30617-9 PMC 바로가기 [Article Type] Article
SARS-CoV-2-specific immune responses in elderly and immunosuppressed participants and patients with hematologic disease or checkpoint inhibition in solid tumors: study protocol of the prospective, observational CoCo immune studyArticle Published on 2022-04-252023-07-08 Journal: BMC Infectious Diseases [Category] COVID19(2023년), [키워드] checkpoint inhibition coronavirus COVID-19 elderly hematology humoral and cellular immunity Immunocompromised people immunogenicity pandemic SARS-CoV-2 Serological testing Social participation Solid tumor. [DOI] 10.1186/s12879-022-07347-w PMC 바로가기
SARS-CoV-2 infection and vaccination trigger long-lived B and CD4+ T lymphocytes with implications for booster strategiesSARS-CoV-2 감염 및 백신 접종은 부스터 전략에 영향을 미치는 수명이 긴 B 및 CD4+ T 림프구를 유발합니다Article Published on 2022-03-152022-09-11 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Adaptive immunity anti-spike immunity antibody antibody levels booster booster dose booster injection breakthrough infections causative agent CD4+ T cell CD4+ T cells CD4+ T lymphocyte Cellular immune response. cellular immunity clinical clinical medicine Cohort CoV COVID-19 COVID-19 infection decay Department detectable Florence funds humoral humoral and cellular immunity Humoral immunity immune response Immunological memory implication individual individuals infected individuals Infection injection Italian Longitudinal evaluation Medicine memory B memory cell Memory cells Ministry of Health mRNA vaccination naïve individuals natural infection neutralization capacity occur performed persistence PROTECT reduced Reinfection restored SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variants SARS-CoV-2-infected individuals severe disease significantly Spike protein supported T cells Tuscany university vaccinated individual vaccinated individuals vaccination [DOI] 10.1172/JCI157990 PMC 바로가기 [Article Type] Article
Longitudinal Tracking of Immune Responses in COVID-19 Convalescents Reveals Absence of Neutralization Activity Against Omicron and Staggered Impairment to Other SARS-CoV-2 Variants of ConcernCOVID-19 회복기의 면역 반응에 대한 종단적 추적은 우려의 다른 SARS-CoV-2 변종에 대한 오미크론 및 시차 손상에 대한 중화 활성의 부재를 나타냅니다Article Published on 2022-03-142022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] activity Against Alpha alpha and delta variants analyzed antibodies association B cell B cells Beta cellular immunity cellular response Cellular responses changes in clearance Cohort concern Correlation analysis COVID-19 decrease Delta Delta variants Evaluating flow cytometry Gamma humoral humoral and cellular immunity humoral immune response IgG antibody IgG titer immune Immunity indicate indicated individual investigated lack long-lasting longitudinal memory memory B cell memory B cells neutralization capacity neutralization test Neutralizing antibodies neutralizing antibody omicron Omicron variants Other Patient patients persistence Perturbation phenotype Prospective Study protection Protective response SARS-CoV-2 SARS-CoV-2 patient SARS-CoV-2 variant SARS-CoV-2 variants sera spike Spike-specific memory B cells surrogate virus neutralization test the disease variant variants variants of concern variants of concern. Viral virus neutralization test was measured Wuhan strain [DOI] 10.3389/fimmu.2022.863039 PMC 바로가기 [Article Type] Article